Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites.

Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites.

Sequence diversity in pathogen antigens is an obstacle to the development of interventions against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 family of variant surface antigens encoded by var genes are adhesion molecules that play a pivotal role in malaria patho...

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Bibliographic Details
Main Authors: Ashfaq Ghumra, Jean-Philippe Semblat, Ricardo Ataide, Carolyne Kifude, Yvonne Adams, Antoine Claessens, Damian N Anong, Peter C Bull, Clare Fennell, Monica Arman, Alfred Amambua-Ngwa, Michael Walther, David J Conway, Lalla Kassambara, Ogobara K Doumbo, Ahmed Raza, J Alexandra Rowe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3330128?pdf=render

Internet

http://europepmc.org/articles/PMC3330128?pdf=render

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