Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins

Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins

Primary human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimers [(gp120/gp41)3] typically exist in a metastable closed conformation (state 1). Binding the CD4 receptor triggers Env to undergo extensive conformational changes to mediate virus entry. We identified specific gp120 resid...

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Bibliographic Details
Main Authors: Alon Herschhorn, Xiaochu Ma, Christopher Gu, John D. Ventura, Luis Castillo-Menendez, Bruno Melillo, Daniel S. Terry, Amos B. Smith, Scott C. Blanchard, James B. Munro, Walther Mothes, Andrés Finzi, Joseph Sodroski
Format: Article
Language:English
Published: American Society for Microbiology 2016-10-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/5/e01598-16

Internet

http://mbio.asm.org/cgi/content/full/7/5/e01598-16

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