Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

Perilipin 5 has been implicated as a modulator of lipase activity and a scaffold linking lipid droplets to mitochondria. Here the authors show that PKA stimulates Peripilin 5 interaction with nuclear PGC-1a and SIRT1 to promote transcription of genes regulating mitochondrial biogenesis and respirati...

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Bibliographic Details
Main Authors: Violeta I. Gallardo-Montejano, Geetu Saxena, Christine M. Kusminski, Chaofeng Yang, John L. McAfee, Lisa Hahner, Kathleen Hoch, William Dubinsky, Vihang A. Narkar, Perry E. Bickel
Format: Article
Language:English
Published: Nature Publishing Group 2016-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12723

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https://doi.org/10.1038/ncomms12723

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