IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease
Immune escape is a fundamental trait of cancer in which the Th1-type cytokine interferon-γ (IFN-γ) seems to play a key role. Among other tumoricidal biochemical pathways, IFN-γ induces the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) in a variety of cells including macrophages, dend...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2010-01-01
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| Series: | International Journal of Tryptophan Research |
| Online Access: | https://doi.org/10.4137/IJTR.S4157 |