The Impact of Immunoglobulin G1 Fc Sialylation on Backbone Amide H/D Exchange

The Impact of Immunoglobulin G1 Fc Sialylation on Backbone Amide H/D Exchange

The usefulness of higher-order structural information provided by hydrogen/deuterium exchange-mass spectrometry (H/DX-MS) for the structural impact analyses of chemical and post-translational antibody modifications has been demonstrated in various studies. However, the structure−function a...

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Bibliographic Details
Main Authors: Felix Kuhne, Lea Bonnington, Sebastian Malik, Marco Thomann, Cecile Avenal, Florian Cymer, Harald Wegele, Dietmar Reusch, Michael Mormann, Patrick Bulau
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Antibodies
Subjects:
hydrogen/deuterium exchange
mass spectrometry
fc glycosylation
antibody conformation
higher-order structure
biopharmaceutical
antibody effector function
fcγr binding
structure-function
sialic acid linkage
Online Access:https://www.mdpi.com/2073-4468/8/4/49

Internet

https://www.mdpi.com/2073-4468/8/4/49

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