Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells

Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells

The idea of using metabolic aberrations as targets for diagnosis or therapeutic intervention has recently gained increasing interest. In a previous study, our group discovered intriguing differences in the oxidative mitochondrial respiration capacity of benign and prostate cancer (PCa) cells. In par...

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Bibliographic Details
Main Authors: Anja Weber, Helmut Klocker, Herbert Oberacher, Erich Gnaiger, Hannes Neuwirt, Natalie Sampson, Iris E. Eder
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
mitochondria
oxidative phosphorylation
acidic tumor microenvironment
Na+-dicarboxylate transporter
succinate
Online Access:http://www.mdpi.com/1422-0067/19/7/2129

Internet

http://www.mdpi.com/1422-0067/19/7/2129

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