BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors

BRAF mutations have been identified as targetable, oncogenic mutations in many cancers. Given the paucity of treatments for primary brain tumors and the poor prognosis associated with high-grade gliomas, BRAF mutations in glioma are of considerable interest. In this review, we present the spectrum o...

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Bibliographic Details
Main Authors: Karisa C. Schreck, Stuart A. Grossman, Christine A. Pratilas
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
MEK
Online Access:https://www.mdpi.com/2072-6694/11/9/1262