Immune-tolerance to human iPS-derived neural progenitors xenografted into the immature cerebellum is overridden by species-specific differences in differentiation timing

Immune-tolerance to human iPS-derived neural progenitors xenografted into the immature cerebellum is overridden by species-specific differences in differentiation timing

Abstract We xeno-transplanted human neural precursor cells derived from induced pluripotent stem cells into the cerebellum and brainstem of mice and rats during prenatal development or the first postnatal week. The transplants survived and started to differentiate up to 1 month after birth when they...

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Bibliographic Details
Main Authors: Giulia Nato, Alessandro Corti, Elena Parmigiani, Elena Jachetti, Daniele Lecis, Mario Paolo Colombo, Domenico Delia, Annalisa Buffo, Lorenzo Magrassi
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79502-9

Internet

https://doi.org/10.1038/s41598-020-79502-9

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