A Model of Cytotoxic Dose-Response Nonlinearities Arising from Adaptive Cell Inventory Management in Tissues

Why do low-level exposures to environmental toxins often elicit over-compensating responses that reduce risk to an organism? Conversely, if these responses improve health, why wait for an environmental challenge to trigger them? This paper presents a mathematical modeling framework that addresses bo...

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Bibliographic Details
Main Author: Louis Anthony (Tony) Cox
Format: Article
Language:English
Published: SAGE Publishing 2005-10-01
Series:Dose-Response
Online Access:https://doi.org/10.2203/dose-response.003.04.005