Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT

Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT

Abstract Background The clinical benefit of allergen-specific immunotherapy (AIT) involves induction of blocking antibodies. It is not clear if these antibodies function via steric hindrance alone or a combination of levels, avidities, and epitope specificities, and clinical outcome cannot be predic...

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Bibliographic Details
Main Authors: Sara Huber, Roland Lang, Markus Steiner, Lorenz Aglas, Fatima Ferreira, Michael Wallner, Thomas Hawranek, Gabriele Gadermaier
Format: Article
Language:English
Published: Wiley 2018-10-01
Series:Clinical and Translational Allergy
Subjects:
Birch pollen
Blocking capacity
Immunotherapy
Bet v 1
IgE
FAB assay
Online Access:http://link.springer.com/article/10.1186/s13601-018-0226-7

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http://link.springer.com/article/10.1186/s13601-018-0226-7

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