Haploidentical CD19/CD22 bispecific CAR-T cells induced MRD-negative remission in a patient with relapsed and refractory adult B-ALL after haploidentical hematopoietic stem cell transplantation

Haploidentical CD19/CD22 bispecific CAR-T cells induced MRD-negative remission in a patient with relapsed and refractory adult B-ALL after haploidentical hematopoietic stem cell transplantation

Abstract Background Chimeric antigen receptor T (CAR-T) cell therapy simultaneously against CD19 and CD22 is an attractive strategy to address the antigen escape relapse after CD19-directed CAR-T cell therapies. However, the potential of optimizing the durability of remission by this approach in pat...

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Bibliographic Details
Main Authors: Hejin Jia, Zhenguang Wang, Yao Wang, Yang Liu, Hanren Dai, Chuan Tong, Yelei Guo, Bo Guo, Dongdong Ti, Xiao Han, Qingming Yang, Zhiqiang Wu, Weidong Han
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Hematology & Oncology
Subjects:
Chimeric antigen receptor
CAR-T
Bispecific CAR-T
GVHD
Haploidentical CAR-T
Online Access:http://link.springer.com/article/10.1186/s13045-019-0741-6

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http://link.springer.com/article/10.1186/s13045-019-0741-6

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