Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative Stress

Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to those observed following an acute and strong oxidati...

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Bibliographic Details
Main Authors: Hocine Rekaik, François-Xavier Blaudin de Thé, Julia Fuchs, Olivia Massiani-Beaudoin, Alain Prochiantz, Rajiv L. Joshi
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715009894