Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury

Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury

The result of a deprivation of oxygen and glucose to the brain, hypoxic–ischemic encephalopathy (HIE), remains the most common cause of death and disability in human neonates globally and is mediated by glutamate toxicity and inflammation. We have previously shown that the enzyme glutamate carboxype...

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Bibliographic Details
Main Authors: O. Arteaga Cabeza, Z. Zhang, E. Smith Khoury, R.A. Sheldon, A. Sharma, F. Zhang, B.S. Slusher, R.M. Kannan, S. Kannan, D.M. Ferriero
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Neuroprotection
Glutamate carboxypeptidase
Nanoparticle
Dendrimer
Neonatal brain injury
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304769

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http://www.sciencedirect.com/science/article/pii/S0969996120304769

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