Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.

Matrix metalloproteinases (Mmps) stimulate tumor invasion and metastasis by degrading the extracellular matrix. Here we reveal an unexpected role for Mmp10 (stromelysin 2) in the maintenance and tumorigenicity of mouse lung cancer stem-like cells (CSC). Mmp10 is highly expressed in oncosphere cultur...

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Bibliographic Details
Main Authors: Verline Justilien, Roderick P Regala, I-Chu Tseng, Michael P Walsh, Jyotica Batra, Evette S Radisky, Nicole R Murray, Alan P Fields
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3335833?pdf=render

Internet

http://europepmc.org/articles/PMC3335833?pdf=render

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