hsa-miR-20b-5p and hsa-miR-363-3p Affect Expression of <i>PTEN</i> and <i>BIM</i> Tumor Suppressor Genes and Modulate Survival of T-ALL Cells In Vitro

hsa-miR-20b-5p and hsa-miR-363-3p Affect Expression of <i>PTEN</i> and <i>BIM</i> Tumor Suppressor Genes and Modulate Survival of T-ALL Cells In Vitro

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy arising from T lymphocyte precursors. We have previously shown by miRNA-seq, that miRNAs from the mir-106a-363 cluster are overexpressed in pediatric T-ALL. In silico analysis indicated their potential involvement in the regulat...

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Bibliographic Details
Main Authors: Monika Drobna, Bronisława Szarzyńska, Roman Jaksik, Łukasz Sędek, Anna Kuchmiy, Tom Taghon, Pieter Van Vlierberghe, Tomasz Szczepański, Michał Witt, Małgorzata Dawidowska
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
oncogenic miRNAs
acute lymphoblastic leukemia
silencing tumor suppressor genes
miRNA cluster
noncoding RNAs in cancer
Online Access:https://www.mdpi.com/2073-4409/9/5/1137

Internet

https://www.mdpi.com/2073-4409/9/5/1137

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