Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core

Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core

Engineering of a “smart” drug delivery system to specifically target tumour cells has been at the forefront of cancer research, having been engineered for safer, more efficient and effective use of chemotherapy for the treatment of cancer. However, selective targeting and choosin...

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Bibliographic Details
Main Authors: Xia Li, Manpreet Sambi, Alexandria DeCarlo, Sergey V. Burov, Roman Akasov, Elena Markvicheva, Cecile Malardier-Jugroot, Myron R. Szewczuk
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Nanomaterials
Subjects:
multicellular tumour spheroids
cyclo-RGDfK(TPP) peptide
folate
amphiphilic alternating copolymer
targeted drug delivery
paclitaxel
5-fluorouracil
curcumin
pH-responsive
Online Access:http://www.mdpi.com/2079-4991/8/8/588

Internet

http://www.mdpi.com/2079-4991/8/8/588

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