Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model

Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model

Carboxy-dehydroevodiamine·HCl (cx-DHED) is a derivative of DHED, which improves memory impairment. Carboxyl modification increases solubility in water, indicating that its bioavailability is higher than that of DHED. Cx-DHED is expected to have better therapeutic effects on Alzheimer's disease...

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Bibliographic Details
Main Authors: Shinwoo Kang, Sungji Ha, Hyunjun Park, Eunjoo Nam, Won Hyuk Suh, Yoo-Hun Suh, Keun-A Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Alzheimer's disease
carboxy-dehydroevodiamine
memory impairment
5xFAD
synaptic destabilization
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00273/full

Internet

https://www.frontiersin.org/article/10.3389/fnbeh.2018.00273/full

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