Hepatitis B virus downregulates vitamin D receptor levels in hepatoma cell lines, thereby preventing vitamin D-dependent inhibition of viral transcription and production

Hepatitis B virus downregulates vitamin D receptor levels in hepatoma cell lines, thereby preventing vitamin D-dependent inhibition of viral transcription and production

Abstract Background Vitamin D is a key immune-modulator that plays a role in the innate and adaptive immune systems. Certain pathogens impair the immune defense by downregulating the vitamin D receptor (VDR) pathway. Low serum levels of vitamin D are associated with increased hepatitis B virus (HBV)...

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Bibliographic Details
Main Authors: Neta Gotlieb, Irena Tachlytski, Yelena Lapidot, Maya Sultan, Michal Safran, Ziv Ben-Ari
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Medicine
Subjects:
Vitamin D
Hepatitis B virus (HBV)
Vitamin D receptor (VDR)
Immune system
Downregulation
Online Access:http://link.springer.com/article/10.1186/s10020-018-0055-0

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http://link.springer.com/article/10.1186/s10020-018-0055-0

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