Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes

Abstract Background The spatial organization of the mammalian genome relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory landscapes that usually match with the presence of topologically as...

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Bibliographic Details
Main Authors: Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Nayuta Yakushiji-Kaminatsui, Asier Ullate-Agote, Denis Duboule
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Biology
Subjects:
Genome architecture
TAD
Polycomb
Tetrapod evolution
Enhancers
Regulatory landscapes
Online Access:http://link.springer.com/article/10.1186/s12915-019-0677-x

Internet

http://link.springer.com/article/10.1186/s12915-019-0677-x

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