Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells

Embryonic pancreatic bud cells, the earliest pancreas-committed cells, generated from human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have been shown to differentiate into mature pancreatic β-cells in vivo, indicating the feasibility of hESC/iPSC-based cell therapy for...

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Bibliographic Details
Main Authors: Taro Toyoda, Shin-Ichi Mae, Hiromi Tanaka, Yasushi Kondo, Michinori Funato, Yoshiya Hosokawa, Tomomi Sudo, Yoshiya Kawaguchi, Kenji Osafune
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506115000161