Mucosal Injuries due to Ribosome-Inactivating Stress and the Compensatory Responses of the Intestinal Epithelial Barrier
Ribosome-inactivating (ribotoxic) xenobiotics are capable of using cleavage and modification to damage 28S ribosomal RNA, which leads to translational arrest. The blockage of global protein synthesis predisposes rapidly dividing tissues, including gut epithelia, to damage from various pathogenic pro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-10-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/3/10/1263/ |