Epithelial C5aR1 Signaling Enhances Uropathogenic Escherichia coli Adhesion to Human Renal Tubular Epithelial Cells

Epithelial C5aR1 Signaling Enhances Uropathogenic Escherichia coli Adhesion to Human Renal Tubular Epithelial Cells

Recent work in a murine model of ascending urinary tract infection has suggested that C5a/C5aR1 interactions play a pathogenic role in the development of renal infection through enhancement of bacterial adhesion/colonization to renal tubular epithelial cells (RTECs). In the present study, we extende...

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Bibliographic Details
Main Authors: Yun Song, Kun-Yi Wu, Weiju Wu, Zhao-Yang Duan, Ya-Feng Gao, Liang-Dong Zhang, Tie Chong, Malgorzata A. Garstka, Wuding Zhou, Ke Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
C5aR1
uropathogenic Escherichia coli
renal tubular epithelial cell
bacterial adhesion/invasion
mannosyl residues
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00949/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00949/full

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