Heparan Sulfate Deficiency in Cartilage: Enhanced BMP-Sensitivity, Proteoglycan Production and an Anti-Apoptotic Expression Signature after Loading

Heparan Sulfate Deficiency in Cartilage: Enhanced BMP-Sensitivity, Proteoglycan Production and an Anti-Apoptotic Expression Signature after Loading

Osteoarthritis (OA) represents one major cause of disability worldwide still evading efficient pharmacological or cellular therapies. Severe degeneration of extracellular cartilage matrix precedes the loss of mobility and disabling pain perception in affected joints. Recent studies showed that a red...

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Bibliographic Details
Main Authors: Matthias Gerstner, Ann-Christine Severmann, Safak Chasan, Andrea Vortkamp, Wiltrud Richter
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
heparan sulfate
proteoglycan
mechanical loading
BMP
chondrocytes
cartilage
Online Access:https://www.mdpi.com/1422-0067/22/7/3726

Internet

https://www.mdpi.com/1422-0067/22/7/3726

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