The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent studies indicate that mTORC1 can activate the transcription factor ATF4 through mechanisms distinct from its canonical induction by the inte...

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Bibliographic Details
Main Authors: Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
metabolism
rapamycin
mTOR
integrated stress response
xCT
cystine
Online Access:https://elifesciences.org/articles/63326

Internet

https://elifesciences.org/articles/63326

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