Accelerated calvarial healing in mice lacking Toll-like receptor 4.

The bone and immune systems are closely interconnected. The immediate inflammatory response after fracture is known to trigger a healing cascade which plays an important role in bone repair. Toll-like receptor 4 (TLR4) is a member of a highly conserved receptor family and is a critical activator of...

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Bibliographic Details
Main Authors: Dan Wang, James R Gilbert, James J Cray, Adam A Kubala, Melissa A Shaw, Timothy R Billiar, Gregory M Cooper
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3468586?pdf=render