Exogenous Iron Increases Fasciocidal Activity and Hepatocellular Toxicity of the Synthetic Endoperoxides OZ78 and MT04

Exogenous Iron Increases Fasciocidal Activity and Hepatocellular Toxicity of the Synthetic Endoperoxides OZ78 and MT04

The synthetic peroxides OZ78 and MT04 recently emerged as fasciocidal drug candidates. However, the effect of iron on fasciocidal activity and hepatocellular toxicity of these compounds is unknown. We investigated the in vitro fasciocidal activity and hepatocellular toxicity of OZ78 and MT04 in abse...

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Bibliographic Details
Main Authors: Karin Brecht, Carla Kirchhofer, Jamal Bouitbir, Francesca Trapani, Jennifer Keiser, Stephan Krähenbühl
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
fasciola hepatica
artesunate
oz78
mt04
hepg2 cells
hepatotoxicity
Online Access:https://www.mdpi.com/1422-0067/20/19/4880

Internet

https://www.mdpi.com/1422-0067/20/19/4880

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