A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization.

A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization.

In age-related macular degeneration (AMD), abnormal sub retinal choroidal neovascularization (CNV) is a major cause of blindness. FR-sema3C is a point mutated form of semaphorin-3C that is resistant to cleavage by furin like pro-protein convertases (FPPC). We have found in previous work that FR-sema...

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Bibliographic Details
Main Authors: Shira Toledano, Huayi Lu, Agustina Palacio, Keren Ziv, Ofra Kessler, Shlomit Schaal, Gera Neufeld, Yoreh Barak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5201251?pdf=render

Internet

http://europepmc.org/articles/PMC5201251?pdf=render

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