Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans.
Prion proteins can adopt self-propagating alternative conformations that account for the infectious nature of transmissible spongiform encephalopathies (TSEs) and the epigenetic inheritance of certain traits in yeast. Recent evidence suggests a similar propagation of misfolded proteins in the spread...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-03-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3610634?pdf=render |