Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

Abstract Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DDIs). As anti-malarials are generally positively char...

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Bibliographic Details
Main Authors: Maarten van der Velden, Albert Bilos, Jeroen J. M. W. van den Heuvel, Sanna R. Rijpma, Evelien G. E. Hurkmans, Robert W. Sauerwein, Frans G. M. Russel, Jan B. Koenderink
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Malaria Journal
Subjects:
Proguanil
Cycloguanil
OCT1
OCT2
MATE1
MATE2-K
Online Access:http://link.springer.com/article/10.1186/s12936-017-2062-y

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http://link.springer.com/article/10.1186/s12936-017-2062-y

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