CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice

CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice

Abstract Recombination activating gene-2 (RAG-2) plays a crucial role in the development of lymphocytes by mediating recombination of T cell receptors and immunoglobulins, and loss of RAG-2 causes severe combined immunodeficiency (SCID) in humans. Rag-2 knockout mice created using homologous recombi...

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Bibliographic Details
Main Authors: Joo-Il Kim, Jin-Sung Park, Hanna Kim, Soo-Kyung Ryu, Jina Kwak, Euna Kwon, Jun-Won Yun, Ki-Taek Nam, Han-Woong Lee, Byeong-Cheol Kang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Laboratory Animal Research
Subjects:
CRISPR/Cas9
Rag-2
histopathology
immunodeficiency
splenic atrophy
thymic atrophy
Online Access:http://link.springer.com/article/10.5625/lar.2018.34.4.166

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http://link.springer.com/article/10.5625/lar.2018.34.4.166

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