Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPC
Abstract Expression of the cellular prion protein (PrPC) is crucial for the development of prion diseases. Amino acid changes in PrPC or a reduced amount of PrPC may modulate disease resistance. The relative abundance of C1, a natural α-cleavage fragment of PrPC, was previously found to be associate...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | deu |
| Published: |
BMC
2021-06-01
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| Series: | Genetics Selection Evolution |
| Online Access: | https://doi.org/10.1186/s12711-021-00646-x |