Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue

Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue

Objective: Non-shivering thermogenesis in brown adipose tissue (BAT) plays a central role in energy homeostasis. Thioesterase superfamily member 1 (Them1), a BAT-enriched long chain fatty acyl-CoA thioesterase, is upregulated by cold and downregulated by warm ambient temperatures. Them1−/− mice exhi...

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Bibliographic Details
Main Authors: Kosuke Okada, Katherine B. LeClair, Yongzhao Zhang, Yingxia Li, Cafer Ozdemir, Tibor I. Krisko, Susan J. Hagen, Rebecca A. Betensky, Alexander S. Banks, David E. Cohen
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877816000351

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http://www.sciencedirect.com/science/article/pii/S2212877816000351

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