N-Propionylmannosamine stimulates axonal elongation in a murine model of sciatic nerve injury

Increasing evidence indicates that sialic acid plays an important role during nerve regeneration. Sialic acids can be modified in vitro as well as in vivo using metabolic oligosaccharide engineering of the N-acyl side chain. N-Propionylmannosamine (ManNProp) increases neurite outgrowth and accelerat...

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Bibliographic Details
Main Authors:	Christian Witzel, Werner Reutter, G Björn Stark, Georgios Koulaxouzidis
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2015-01-01
Series:	Neural Regeneration Research
Subjects:	microtubule axon kinesin-5 Eg5 regeneration monastrol molecular motor protein aging neurodegenerative disorders telomere shortening MSCs cellular therapy traumatic brain injury spinal cord injuries dual diagnosis diagnosis complications rehabilitation post-concussion syndrome brain concussion blood brain barrier phage display peptide library nanocarrier targeting Schwann cells neurite outgrowth neuromuscular junction (NMJ) multiple sclerosis TGF-β/BMP-7/Smad signaling myogenic differentiation Trf3 tumor suppression nerve regeneration bone marrow mesenchymal stem cells cerebral ischemia tail vein injection middle cerebral artery occlusion cell therapy neuroprotection brain injury neuroimaging ferumoxytol superparamagnetic iron oxide particles human adipose-derived stem cells intracerebral injection magnetic resonance imaging enhanced susceptibility-weighted angiography image modified neurological severity scores rats Prussian blue staining neural regeneration non-invasive brain stimulation transcranial magnetic stimulation neurotrophic factor brain-derived neurotrophic factor neuroplasticity hippocampus cognitive function curcumin neurons HIV-1 gp120 V3 loop plasticity HIV-associated neurocognitive disorders output/input curve long-term potentiation excitatory postsynaptic potential paired-pulse facilitation Ca 2+ synaptosome NSFC grants hydrogen sulfide cerebral ischemia/reperfusion injury P2X 7 receptor 2 3 5-triphenyl-2H-tetrazolium chloride staining animal model protection sodium hydrosulfide immunofluorescence NSFC grant γ-aminobutyric acid glial fibrillary acidic protein glutamic acid decarboxylase neurotoxicity weaning organ index cerebrum cortex glutamate p53 tumor suppressor gene family cerebral ischemia/reperfusion pyramidal neurons CA1 region delayed neuronal death immunohistochemistry western blotting spinal cord injury rapamycin Wnt/β-catenin signaling pathway apoptosis caspase-3 loss of neurons hydrogen-rich saline reactive oxygen species physiological saline oxidative stress Basso Beattie and Bresnahan score malondialdehyde superoxide dismutase calcitonin gene-related peptide peripheral nerve injury rabbits sciatic nerve injury autologous nerve repair polylactic glycolic acid conduit extracellular matrix gel grafting stress relaxation creep viscoelasticity histomorphology electrophysiology pain sense model dorsal root ganglion primary sensory neuron glycosylated membrane protein sialic acid cell electrophoresis electrophoresis velocity heat-hyperalgesia behavior hyperalgesia neuraminidase N-propionylmannosamine glycoengineering sciatic nerve peripheral nerve branching arborisation Thy1-YFP mouse
Online Access:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=6;spage=976;epage=981;aulast=Witzel

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=6;spage=976;epage=981;aulast=Witzel

N-Propionylmannosamine stimulates axonal elongation in a murine model of sciatic nerve injury

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