Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments

Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments

Regulated thin filaments (RTFs) tightly control striated muscle contraction through calcium binding to troponin, which enables tropomyosin to expose myosin-binding sites on actin. Myosin binding holds tropomyosin in an open position, exposing more myosin-binding sites on actin, leading to cooperativ...

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Bibliographic Details
Main Authors: Quentin M Smith, Alessio V Inchingolo, Madalina-Daniela Mihailescu, Hongsheng Dai, Neil M Kad
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
cooperativity
muscle
actin
fluorescence imaging
regulation
calcium
Online Access:https://elifesciences.org/articles/69184

Internet

https://elifesciences.org/articles/69184

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