Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma

Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma

<p>Abstract</p> <p>Background</p> <p>Recently, S-1, a novel 5-fluorouracil (5-FU)-based agent containing the strong dihydropyrimidine dehydrogenase (DPD) inhibitor, 5-chloro-2,4-dihydropyrimidine (CDHP) has been clinically used to treat various non-urothelial carcinomas...

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Bibliographic Details
Main Authors: Ide Hiroki, Kikuchi Eiji, Hasegawa Masanori, Kozakai Norihide, Kosaka Takeo, Miyajima Akira, Oya Mototsugu
Format: Article
Language:English
Published: BMC 2012-09-01
Series:BMC Cancer
Subjects:
Urothelial carcinoma
S-1
5-fluorouracil
Thymidylate synthase
Dihydropyrimidine dehydrogenase
Online Access:http://www.biomedcentral.com/1471-2407/12/420

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http://www.biomedcentral.com/1471-2407/12/420

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