Bcl10 Links Saturated Fat Overnutrition with Hepatocellular NF-κB Activation and Insulin Resistance

Bcl10 Links Saturated Fat Overnutrition with Hepatocellular NF-κB Activation and Insulin Resistance

Excess serum free fatty acids (FFAs) are fundamental to the pathogenesis of insulin resistance. With high-fat feeding, FFAs activate NF-κB in target tissues, initiating negative crosstalk with insulin signaling. However, the mechanisms underlying FFA-dependent NF-κB activation remain unclear. Here,...

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Bibliographic Details
Main Authors: Matthew Van Beek, Katherine I. Oravecz-Wilson, Phillip C. Delekta, Shufang Gu, Xiangquan Li, Xiaohong Jin, Ingrid J. Apel, Katy S. Konkle, Yongjia Feng, Daniel H. Teitelbaum, Jürgen Ruland, Linda M. McAllister-Lucas, Peter C. Lucas
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712001192

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http://www.sciencedirect.com/science/article/pii/S2211124712001192

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