Effects of α subunit substitutions on the oxidation of βCys93 and the stability of sickle cell hemoglobin
The β subunit substitutions, F41Y and K82D, in sickle cell hemoglobin (Hb) (βE6 V) provides significant resistance to oxidative stress by shielding βCys93 from the oxidizing ferryl heme. We evaluated the oxidative resistance of βCys93 to hydrogen peroxide (H2O2) in α subunit mutations in βE6 V (at b...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-01-01
|
| Series: | Redox Report |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/13510002.2020.1834250 |