Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization

Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization

The activation of human bronchial fibroblasts by transforming growth factor-β1 (TGF-β1) leads to the formation of highly contractile myofibroblasts in the process of the fibroblast–myofibroblast transition (FMT). This process is crucial for subepithelial fibrosis and bron...

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Bibliographic Details
Main Authors: Milena Paw, Dawid Wnuk, Dominika Kądziołka, Aleksandra Sęk, Sławomir Lasota, Jarosław Czyż, Zbigniew Madeja, Marta Michalik
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
fibroblast-to-myofibroblast transition
TGF-β/Smad signaling
fenofibrate
bronchial asthma
actin cytoskeleton architecture
connexin 43
Online Access:http://www.mdpi.com/1422-0067/19/9/2571

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http://www.mdpi.com/1422-0067/19/9/2571

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