SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

Recent genomic and scRNA-seq analyses of melanoma demonstrated a lack of recurrent genetic drivers of metastasis, while identifying common transcriptional states correlating with invasion or drug resistance. To test whether transcriptional adaptation can drive melanoma progression, we made use of a...

Full description

Bibliographic Details
Main Authors: Maurizio Fazio, Ellen van Rooijen, Michelle Dang, Glenn van de Hoek, Julien Ablain, Jeffrey K Mito, Song Yang, Andrew Thomas, Jonathan Michael, Tania Fabo, Rodsy Modhurima, Patrizia Pessina, Charles K Kaufman, Yi Zhou, Richard M White, Leonard I Zon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
melanoma
SATB2
metastasis
neural crest
drug resistance
epigenetics
Online Access:https://elifesciences.org/articles/64370

Internet

https://elifesciences.org/articles/64370

Similar Items