Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats

• Main Authors: Akiko Kawade, Aya Yamamura, Moe Fujiwara, Saki Kobayashi, Shiho Mori, Chihiro Horii, Akari Hiraku, Sayo Suzumura, Kikuo Tsukamoto, Naoki Ohara, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura
• Format: Article
• Language: English
• Published: Elsevier 2021-09-01
• Series: Journal of Pharmacological Sciences
• Subjects: Pulmonary hypertension; Monocrotaline; Age
• Online Access: http://www.sciencedirect.com/science/article/pii/S1347861321000542
• ISSN: 1347-8613

Pulmonary arterial hypertension (PAH) is a rare, progressive, and fatal cardiovascular/lung disease. The incidence rate is affected by age. Monocrotaline (MCT, 60 mg/kg)-treated rats are widely used as an experimental PAH model. Here, we found that young rats died at a mean of 23.4 days after MCT injection, whereas adult rats survived for over 42 days. However, young (7-week-old) and adult (20-week-old) MCT-treated rats developed PAH, and had upregulated Ca2+-sensing receptor and transient receptor potential canonical subfamily 6 channel expression in pulmonary arteries. The present study provides novel information for elucidating the mechanism underlying the age difference in PAH patients.