Prolonged, low-dose anti-thymocyte globulin, combined with CTLA4-Ig, promotes engraftment in a stringent transplant model.

Prolonged, low-dose anti-thymocyte globulin, combined with CTLA4-Ig, promotes engraftment in a stringent transplant model.

Despite significant nephrotoxicity, calcineurin inhibitors (CNIs) remain the cornerstone of immunosuppression in solid organ transplantation. We, along with others, have reported tolerogenic properties of anti-thymocyte globulin (ATG, Thymoglobulin®), evinced by its ability both to spare Tregs from...

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Bibliographic Details
Main Authors: Francesca D'Addio, Olaf Boenisch, Ciara N Magee, Melissa Y Yeung, Xueli Yuan, Bechara Mfarrej, Andrea Vergani, Mohammed Javeed Ansari, Paolo Fiorina, Nader Najafian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3542267?pdf=render

Internet

http://europepmc.org/articles/PMC3542267?pdf=render

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