Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation.

Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation.

Although anti-retroviral therapy (ART) is highly effective in suppressing HIV replication, it fails to eradicate the virus from HIV-infected individuals. Stable latent HIV reservoirs are rapidly established early after HIV infection. Therefore, effective strategies for eradication of the HIV reservo...

Full description

Bibliographic Details
Main Authors: Guochun Jiang, Erica A Mendes, Philipp Kaiser, Daniel P Wong, Yuyang Tang, Ivy Cai, Anne Fenton, Gregory P Melcher, James E K Hildreth, George R Thompson, Joseph K Wong, Satya Dandekar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4520526?pdf=render

Internet

http://europepmc.org/articles/PMC4520526?pdf=render

Similar Items