Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes

Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes

Background: Infection with human papillomavirus (HPV) is a critical factor in the development of cervical cancer. Smoking is an additional risk factor. Tobacco smoke carcinogens, such as benzo[a]pyrene (B[a]P), and their cytochrome P450-related metabolites are present in significantly higher levels...

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Bibliographic Details
Main Authors: Neil Trushin, Samina Alam, Karam El-Bayoumy, Jacek Krzeminski, Shantu G Amin, Jenny Gullett, Craig Meyers, Bogdan Prokopczyk
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2012-01-01
Series:Journal of Carcinogenesis
Subjects:
Benzo[a]pyrene metabolism
benzo[a]pyrene
cervical cancer
cigarette smoke carcinogen
cytochrome P450 1A1
cytochrome P450 1B1
human papillomavirus
Online Access:http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2012;volume=11;issue=1;spage=1;epage=1;aulast=Trushin

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http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2012;volume=11;issue=1;spage=1;epage=1;aulast=Trushin

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