Muscle IGF-1-Induced Skeletal Muscle Hypertrophy Evokes Higher Insulin Sensitivity and Carbohydrate Use as Preferential Energy Substrate

Muscle IGF-1-Induced Skeletal Muscle Hypertrophy Evokes Higher Insulin Sensitivity and Carbohydrate Use as Preferential Energy Substrate

We characterized the metabolic profile of transgenic mice exhibiting enhanced muscle mass driven by increased mIGF-1 expression (MLC/mIGF-1). As expected, 6-month-old MLC/mIGF-1 mice were heavier than age-matched wild type (WT) mice (37.4 ± 0.3 versus 31.8 ± 0.6 g, resp.). MLC/mIGF-1 mice had higher...

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Bibliographic Details
Main Authors: Marcelo Augusto Christoffolete, William Jose Silva, Gracielle Vieira Ramos, Mirella Ribeiro Bento, Monique Oliveira Costa, Miriam Oliveira Ribeiro, Maristela Mitiko Okamoto, Tania Helena Lohmann, Ubiratan Fabres Machado, Antonio Musarò, Anselmo Sigari Moriscot
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/282984

Internet

http://dx.doi.org/10.1155/2015/282984

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