Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus

Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus

The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented. These include spinocerebellar ataxia, epilepsy and mental retardation (SCAR12, OMIM: 614322) and early infantile epileptic encephalopathy (EIEE2...

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Bibliographic Details
Main Authors: Tabish Hussain, Hyunsuk Kil, Bharathi Hattiangady, Jaeho Lee, Maheedhar Kodali, Bing Shuai, Sahithi Attaluri, Yoko Takata, Jianjun Shen, Martin C. Abba, Ashok K. Shetty, C. Marcelo Aldaz
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Neurobiology of Disease
Subjects:
Wwox
Epilepsy
Hippocampus
GABA-ergic interneurons
Microgliosis
Astrogliosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118306612

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http://www.sciencedirect.com/science/article/pii/S0969996118306612

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