Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.

Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.

HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs. We have recently identified a llama single-domain antibody (Nb190) as the first inhibitor targeting the Rev multimer...

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Bibliographic Details
Main Authors: Thomas Vercruysse, Eline Boons, Tom Venken, Els Vanstreels, Arnout Voet, Jan Steyaert, Marc De Maeyer, Dirk Daelemans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23565213/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23565213/pdf/?tool=EBI

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