Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis
Atherosclerosis can be regarded as a chronic inflammatory state, in which macrophages play different and important roles. Phagocytic proinflammatory cells populate growing atherosclerotic lesions, where they actively participate in cholesterol accumulation. Moreover, macrophages promote formation of...
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doaj-b2bfe801a0844f51a915f63ebc3fd3fe2020-11-24T23:11:29ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/95824309582430Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome AnalysisYuri V. Bobryshev0Ekaterina A. Ivanova1Dimitry A. Chistiakov2Nikita G. Nikiforov3Alexander N. Orekhov4Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, RussiaDepartment of Development and Regeneration, KU Leuven, 3000 Leuven, BelgiumDepartment of Molecular Genetic Diagnostics and Cell Biology, Institute of Pediatrics, Research Center for Children’s Health, Moscow 119991, RussiaInstitute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, RussiaInstitute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, RussiaAtherosclerosis can be regarded as a chronic inflammatory state, in which macrophages play different and important roles. Phagocytic proinflammatory cells populate growing atherosclerotic lesions, where they actively participate in cholesterol accumulation. Moreover, macrophages promote formation of complicated and unstable plaques by maintaining proinflammatory microenvironment. At the same time, anti-inflammatory macrophages contribute to tissue repair and remodelling and plaque stabilization. Macrophages therefore represent attractive targets for development of antiatherosclerotic therapy, which can aim to reduce monocyte recruitment to the lesion site, inhibit proinflammatory macrophages, or stimulate anti-inflammatory responses and cholesterol efflux. More studies are needed, however, to create a comprehensive classification of different macrophage phenotypes and to define their roles in the pathogenesis of atherosclerosis. In this review, we provide an overview of the current knowledge on macrophage diversity, activation, and plasticity in atherosclerosis and describe macrophage-based cellular tests for evaluation of potential antiatherosclerotic substances.http://dx.doi.org/10.1155/2016/9582430 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuri V. Bobryshev Ekaterina A. Ivanova Dimitry A. Chistiakov Nikita G. Nikiforov Alexander N. Orekhov |
spellingShingle |
Yuri V. Bobryshev Ekaterina A. Ivanova Dimitry A. Chistiakov Nikita G. Nikiforov Alexander N. Orekhov Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis BioMed Research International |
author_facet |
Yuri V. Bobryshev Ekaterina A. Ivanova Dimitry A. Chistiakov Nikita G. Nikiforov Alexander N. Orekhov |
author_sort |
Yuri V. Bobryshev |
title |
Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis |
title_short |
Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis |
title_full |
Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis |
title_fullStr |
Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis |
title_full_unstemmed |
Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis |
title_sort |
macrophages and their role in atherosclerosis: pathophysiology and transcriptome analysis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
Atherosclerosis can be regarded as a chronic inflammatory state, in which macrophages play different and important roles. Phagocytic proinflammatory cells populate growing atherosclerotic lesions, where they actively participate in cholesterol accumulation. Moreover, macrophages promote formation of complicated and unstable plaques by maintaining proinflammatory microenvironment. At the same time, anti-inflammatory macrophages contribute to tissue repair and remodelling and plaque stabilization. Macrophages therefore represent attractive targets for development of antiatherosclerotic therapy, which can aim to reduce monocyte recruitment to the lesion site, inhibit proinflammatory macrophages, or stimulate anti-inflammatory responses and cholesterol efflux. More studies are needed, however, to create a comprehensive classification of different macrophage phenotypes and to define their roles in the pathogenesis of atherosclerosis. In this review, we provide an overview of the current knowledge on macrophage diversity, activation, and plasticity in atherosclerosis and describe macrophage-based cellular tests for evaluation of potential antiatherosclerotic substances. |
url |
http://dx.doi.org/10.1155/2016/9582430 |
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