The Increase in IL-1β in the Early Stage of Heatstroke Might Be Caused by Splenic Lymphocyte Pyroptosis Induced by mtROS-Mediated Activation of the NLRP3 Inflammasome

The Increase in IL-1β in the Early Stage of Heatstroke Might Be Caused by Splenic Lymphocyte Pyroptosis Induced by mtROS-Mediated Activation of the NLRP3 Inflammasome

Interleukin-1β (IL-1β) is important for the pathological process of heatstroke (HS), although little is known regarding the main source of the IL-1β produced during the early stage of HS. In this study, heat stress led splenic lymphocytes to death with generation of inflammatory cytokines. The same...

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Bibliographic Details
Main Authors: Gong Wang, Tingting Shen, Ping Li, Zhen Luo, Yulong Tan, Genlin He, Xiaoliang Zhang, Ju Yang, Jun Liu, Yuan Wang, He Tang, Xue Luo, Xuesen Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
heatstroke
NLRP3 inflammasome
pyroptosis
mtROS
splenic lymphocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02862/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02862/full

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