A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-Diones with Aminocrotonic Acid Esters

A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-Diones with Aminocrotonic Acid Esters

A new synthetic approach to polyfunctional hexahydropyrrolo[3,4-b]pyrroles was developed based on cyclization of N-arylbromomaleimides with aminocrotonic acid esters. A highly chemo- and stereoselective reaction is a Hantzsch-type domino process, involving the steps of initial nucleophilic C-additio...

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Bibliographic Details
Main Authors: Khidmet Shikhaliev, Artem Sabynin, Valeri Sekirin, Michael Krysin, Fedor Zubkov, Kristina Yankina
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
pyrrole
pyrrolo[3,4-b]pyrrole
bromomaleimide
aminocrotonate
domino reaction
Online Access:https://www.mdpi.com/1420-3049/22/11/2035

Internet

https://www.mdpi.com/1420-3049/22/11/2035

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