Novel reporter mouse models useful for evaluating in vivo gene editing and for optimization of methods of delivering genome editing tools

Novel reporter mouse models useful for evaluating in vivo gene editing and for optimization of methods of delivering genome editing tools

The clustered regularly interspersed palindromic repeats (CRISPR) system is a powerful genome-editing tool to modify genomes, virtually in any species. The CRISPR tool has now been utilized in many areas of medical research, including gene therapy. Although several proof-of-concept studies show the...

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Bibliographic Details
Main Authors: Hiromi Miura, Jurai Imafuku, Aki Kurosaki, Masahiro Sato, Yongjie Ma, Guisheng Zhang, Akiko Mizutani, Kenya Kamimura, Channabasavaiah B. Gurumurthy, Dexi Liu, Masato Ohtsuka
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
CRISPR
gene therapy
in vivo gene editing
EGFP
transgenic mice
genome editing efficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000743

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http://www.sciencedirect.com/science/article/pii/S2162253121000743

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